Nucleolar stress: is there a reverse version?

ABSTRACT: The nucleolus is a dynamic structure that has roles in various physiological and pathophysiological processes. Perturbations on many aspects of the nucleolar functions are thought to cause "nucleolar stress", which occurs in response to a variety of chemotherapeutic drugs. The main characteristic changes of nucleolar stress include: 1) reduction of the size and volume of the nucleolus; 2) inhibition of RNA Pol I-mediated rRNA synthesis; and 3) nucleoplasmic translocation of nucleolar stress-related proteins. In studying the apoptosis-inducing effect of the natural compound lovastatin (LV) on breast cancer stem cells, we unexpectedly uncovered a novel form of nucleolar stress, which we call "reverse nucleolar stress". In our system, the canonical nucleolus stress inducer doxorubicin caused

SUBMITTER: Lu L 

PROVIDER: S-EPMC6216007 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature