Dataset Information

The Role of Lifestyle Factors and Sleep Duration for Late-Onset Dementia: A Cohort Study.

ABSTRACT: BACKGROUND:The role of lifestyle factors and sleep for dementia is uncertain. OBJECTIVE:To examine the associations of major lifestyle factors and sleep duration with risk of late-onset dementia. METHODS:We used data from a population-based cohort of 28,775 Swedish adults who were ?65 years of age and completed a questionnaire about lifestyle and other modifiable factors in the autumn of 1997. Dementia cases were ascertained by linkage with the Swedish National Patient Register. RESULTS:During a mean follow-up of 12.6 years, dementia was diagnosed among 3,755 participants (mean age at diagnosis 83.2±5.1 years). There were no associations of an overall healthy diet (defined by a modified Dietary Approaches to Stop Hypertension Diet score or a Mediterranean diet score), alcohol and coffee consumption, or physical activity with dementia incidence. Compared with never smokers, dementia risk was increased in former and current smokers (hazard ratio [95% confidence interval] = 1.13 [1.04-1.23] and 1.10 [1.00-1.21], respectively). Extended time of sleep (>9 h per night) was associated with an increased risk of dementia. However, this association appeared to be related to a reverse causation effect since the association did not remain after exclusion of cases diagnosed within the first five or ten years of follow-up. CONCLUSIONS:This study found no evidence that major lifestyle factors, aside from smoking, or sleep duration influence the risk of dementia.

SUBMITTER: Larsson SC

PROVIDER: S-EPMC6218132 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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The Role of Lifestyle Factors and Sleep Duration for Late-Onset Dementia: A Cohort Study.

Larsson Susanna C SC Wolk Alicja A

Journal of Alzheimer's disease : JAD 20180101 2

<h4>Background</h4>The role of lifestyle factors and sleep for dementia is uncertain.<h4>Objective</h4>To examine the associations of major lifestyle factors and sleep duration with risk of late-onset dementia.<h4>Methods</h4>We used data from a population-based cohort of 28,775 Swedish adults who were ≥65 years of age and completed a questionnaire about lifestyle and other modifiable factors in the autumn of 1997. Dementia cases were ascertained by linkage with the Swedish National Patient Regi ...[more]

PMID: 30320581

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Project description:BackgroundLate onset depression (LOD) often occurs in the context of vascular disease and may be associated with risk of dementia. Aspirin is widely used to reduce the risk of cardiovascular disease and stroke. However, its role in patients with LOD and risk of dementia remains inconclusive. Materials and Methods. A population-based study was conducted using data from National Health Insurance of Taiwan during 1996-2009. Patients fulfil diagnostic criteria for LOD with or without subsequent dementia (incident dementia) and among whom users of aspirin (75 mg daily for at least 6 months) were identified. The time-dependent Cox proportional hazards model was applied for multivariate analyses. Propensity scores with the one-to-one nearest-neighbor matching model were used to select matching patients. Cumulative incidence of incident dementia after diagnosis of LOD was calculated by Kaplan-Meier Method.ResultsA total of 6028 (13.4%) and 40,411 (86.6%) patients were defined as, with and without diagnosis of LOD, among whom 2,424 (41.9%) were aspirin users. Patients with LOD had more comorbidities such as cardiovascular diseases, diabetes, and hypertension comparing to those without LOD. Among patients with LOD, aspirin users had lower incidence of subsequent incident dementia than non-users (Hazard Ratio = 0.734, 95% CI 0.641-0.841, p < 0.001). After matching aspirin users with non-users by propensity scores-matching method, the cumulative incidence of incident dementia was significantly lower in aspirin users of LOD patients (p < 0.001). After matching aspirin users with non-users by propensity scores-matching method, the cumulative incidence of incident dementia was significantly lower in aspirin users of LOD patients (.ConclusionsAspirin may be associated with a lower risk of incident dementia in patients with LOD. This beneficial effect of aspirin in LOD patients needs validation in prospective clinical trials and our results should be interpreted with caution.

Dataset Information

The Role of Lifestyle Factors and Sleep Duration for Late-Onset Dementia: A Cohort Study.

Publications

The Role of Lifestyle Factors and Sleep Duration for Late-Onset Dementia: A Cohort Study.

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