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The Role of Lifestyle Factors and Sleep Duration for Late-Onset Dementia: A Cohort Study.


ABSTRACT: BACKGROUND:The role of lifestyle factors and sleep for dementia is uncertain. OBJECTIVE:To examine the associations of major lifestyle factors and sleep duration with risk of late-onset dementia. METHODS:We used data from a population-based cohort of 28,775 Swedish adults who were ?65 years of age and completed a questionnaire about lifestyle and other modifiable factors in the autumn of 1997. Dementia cases were ascertained by linkage with the Swedish National Patient Register. RESULTS:During a mean follow-up of 12.6 years, dementia was diagnosed among 3,755 participants (mean age at diagnosis 83.2±5.1 years). There were no associations of an overall healthy diet (defined by a modified Dietary Approaches to Stop Hypertension Diet score or a Mediterranean diet score), alcohol and coffee consumption, or physical activity with dementia incidence. Compared with never smokers, dementia risk was increased in former and current smokers (hazard ratio [95% confidence interval] = 1.13 [1.04-1.23] and 1.10 [1.00-1.21], respectively). Extended time of sleep (>9 h per night) was associated with an increased risk of dementia. However, this association appeared to be related to a reverse causation effect since the association did not remain after exclusion of cases diagnosed within the first five or ten years of follow-up. CONCLUSIONS:This study found no evidence that major lifestyle factors, aside from smoking, or sleep duration influence the risk of dementia.

SUBMITTER: Larsson SC 

PROVIDER: S-EPMC6218132 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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The Role of Lifestyle Factors and Sleep Duration for Late-Onset Dementia: A Cohort Study.

Larsson Susanna C SC   Wolk Alicja A  

Journal of Alzheimer's disease : JAD 20180101 2


<h4>Background</h4>The role of lifestyle factors and sleep for dementia is uncertain.<h4>Objective</h4>To examine the associations of major lifestyle factors and sleep duration with risk of late-onset dementia.<h4>Methods</h4>We used data from a population-based cohort of 28,775 Swedish adults who were ≥65 years of age and completed a questionnaire about lifestyle and other modifiable factors in the autumn of 1997. Dementia cases were ascertained by linkage with the Swedish National Patient Regi  ...[more]

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