Alterations in exosomal miRNA profile upon epithelial-mesenchymal transition in human lung cancer cell lines.

ABSTRACT:

Background

Epithelial-mesenchymal transition (EMT) is regarded as a critical event during tumor metastasis. Recent studies have revealed changes and the contributions of proteins in/on exosomes during EMT. Besides proteins, microRNA (miRNA) is another important functional component of exosomes. We hypothesized that the miRNA profile of exosomes may change following EMT and these exosomal miRNAs may in return promote EMT, migration and invasion of cancer cells.

Results

The small RNA profile of exosomes was altered following EMT. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis revealed that the specific miRNAs of M-exosomes have the potential to drive signal transduction networks in EMT and cancer progression. Co-culture experiments confirmed that M-exosomes ca

SUBMITTER: Tang YT 

PROVIDER: S-EPMC6219194 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature