Unknown

Dataset Information

0

The kinematic recovery process of rhesus monkeys after spinal cord injury.


ABSTRACT: After incomplete spinal cord injury (SCI), neural circuits may be plastically reconstructed to some degree, resulting in extensive functional locomotor recovery. The present study aimed to observe the post-SCI locomotor recovery of rhesus monkey hindlimbs and compare the recovery degrees of different hindlimb parts, thus revealing the recovery process of locomotor function. Four rhesus monkeys were chosen for thoracic hemisection injury. The hindlimb locomotor performance of these animals was recorded before surgery, as well as 6 and 12 weeks post-lesion. Via principal component analysis, the relevant parameters of the limb endpoint, pelvis, hindlimb segments, and joints were processed and analyzed. Twelve weeks after surgery, partial kinematic recovery was observed at the limb endpoint, shank, foot, and knee joints, and the locomotor performance of the ankle joint even recovered to the pre-lesion level; the elevation angle of the thigh and hip joints showed no obvious recovery. Generally, different parts of a monkey hindlimb had different spontaneous recovery processes; specifically, the closer the part was to the distal end, the more extensive was the locomotor function recovery. Therefore, we speculate that locomotor recovery may be attributed to plastic reconstruction of the motor circuits that are mainly composed of corticospinal tract. This would help to further understand the plasticity of motor circuits after spinal cord injury.

SUBMITTER: Wei RH 

PROVIDER: S-EPMC6219880 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

altmetric image

Publications

The kinematic recovery process of rhesus monkeys after spinal cord injury.

Wei Rui-Han RH   Zhao Can C   Rao Jia-Sheng JS   Zhao Wen W   Zhou Xia X   Tian Peng-Yu PY   Song Wei W   Ji Run R   Zhang Ai-Feng AF   Yang Zhao-Yang ZY   Li Xiao-Guang XG  

Experimental animals 20180516 4


After incomplete spinal cord injury (SCI), neural circuits may be plastically reconstructed to some degree, resulting in extensive functional locomotor recovery. The present study aimed to observe the post-SCI locomotor recovery of rhesus monkey hindlimbs and compare the recovery degrees of different hindlimb parts, thus revealing the recovery process of locomotor function. Four rhesus monkeys were chosen for thoracic hemisection injury. The hindlimb locomotor performance of these animals was re  ...[more]

Similar Datasets

| S-EPMC9272921 | biostudies-literature
| S-EPMC6004491 | biostudies-literature
| S-EPMC4072074 | biostudies-literature
| S-EPMC8643056 | biostudies-literature
| S-EPMC2895144 | biostudies-other
| S-EPMC9396932 | biostudies-literature
| S-EPMC7445170 | biostudies-literature
| S-EPMC5110012 | biostudies-literature
| S-EPMC4086463 | biostudies-literature
| S-EPMC7197201 | biostudies-literature