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Photocatalyic Appel reaction enabled by copper-based complexes in continuous flow.

ABSTRACT: A copper-based photocatalyst, Cu(tmp)(BINAP)BF₄, was found to be active in a photoredox Appel-type conversion of alcohols to bromides. The catalyst was identified from a screening of 50 complexes and promoted the transformation of primary and secondary alcohols to their corresponding bromides and carboxylic acids to their anhydrides. The protocol was also amendable and optimized under continuous flow conditions.

SUBMITTER: Minozzi C

PROVIDER: S-EPMC6244115 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Photocatalyic Appel reaction enabled by copper-based complexes in continuous flow.

Minozzi Clémentine C Grenier-Petel Jean-Christophe JC Parisien-Collette Shawn S Collins Shawn K SK

Beilstein journal of organic chemistry 20181030

A copper-based photocatalyst, Cu(tmp)(BINAP)BF<sub>4</sub>, was found to be active in a photoredox Appel-type conversion of alcohols to bromides. The catalyst was identified from a screening of 50 complexes and promoted the transformation of primary and secondary alcohols to their corresponding bromides and carboxylic acids to their anhydrides. The protocol was also amendable and optimized under continuous flow conditions. ...[more]

PMID: 30498523

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