Cross Talk between MarR-Like Transcription Factors Coordinates the Regulation of Motility in Uropathogenic Escherichia coli.

ABSTRACT: The MarR-like protein PapX represses the transcription of the flagellar master regulator genes flhDC in uropathogenic Escherichia coli (UPEC), the primary cause of uncomplicated urinary tract infections (UTIs). PapX is encoded by the pap operon, which also encodes the adherence factors termed P fimbriae. Both adherence and motility are critical for productive colonization of the urinary tract. However, the mechanisms involved in coordinating the transition between adherence and motility are not well characterized. UPEC strain CFT073 carries both papX and a homolog, focX, located in the foc operon encoding F1C fimbriae. In this study, we characterized the dose effects of "X" genes on flagellar gene expression and cross talk between focX and papX We found that both FocX and PapX repress flhD

SUBMITTER: Luterbach CL 

PROVIDER: S-EPMC6246914 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature