Fluid administration rate for uncontrolled intraabdominal hemorrhage in swine.
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ABSTRACT: Background
We hypothesized that slow crystalloid resuscitation would result in less blood loss and a smaller hemoglobin decrease compared to a rapid resuscitation during uncontrolled hemorrhage.Methods
Anesthetized, splenectomized domestic swine underwent hepatic lobar hemitransection. Lactated Ringers was given at 150 or 20 mL/min IV (rapid vs. slow, respectively, N = 12 per group; limit of 100 mL/kg). Primary endpoints were blood loss and serum hemoglobin; secondary endpoints included survival, vital signs, coagulation parameters, and blood gases.Results
The slow group had a less blood loss (1.6 vs. 2.7 L, respectively) and a higher final hemoglobin concentration (6.0 vs. 3.4 g/dL).Conclusions
Using a fixed volume of crystalloid resuscitation in this porcine model of uncontrolled intraabdominal hemorrhage, a slow IV infusion rate produced less blood loss and a smaller hemoglobin decrease compared to rapid infusion.
SUBMITTER: Yanala UR
PROVIDER: S-EPMC6264836 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
Fluid administration rate for uncontrolled intraabdominal hemorrhage in swine.
Yanala Ujwal R UR Johanning Jason M JM Pipinos Iraklis I II High Robin R RR Larsen Gustavo G Velander William H WH Carlson Mark A MA
PloS one 20181129 11
<h4>Background</h4>We hypothesized that slow crystalloid resuscitation would result in less blood loss and a smaller hemoglobin decrease compared to a rapid resuscitation during uncontrolled hemorrhage.<h4>Methods</h4>Anesthetized, splenectomized domestic swine underwent hepatic lobar hemitransection. Lactated Ringers was given at 150 or 20 mL/min IV (rapid vs. slow, respectively, N = 12 per group; limit of 100 mL/kg). Primary endpoints were blood loss and serum hemoglobin; secondary endpoints i ...[more]
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