Synthesis of N-substituted acridinediones and polyhydroquinoline derivatives in refluxing water.

ABSTRACT: Acridinediones were synthesized by the one-pot Hantzsch condensation of an aromatic aldehyde, 5,5-dimethyl-1,3-cyclohexanedione, and aniline/4-methylaniline in refluxing water. This method has then been extended to the four-component reaction of an aromatic aldehyde, 5,5-dimethyl-1,3-cyclohexanedione, ethyl acetoacetate and ammonium acetate for the synthesis of polyhydroquinoline derivatives. This is an environmentally friendly and efficient procedure providing  good to excellent yields.

SUBMITTER: Xia JJ 

PROVIDER: S-EPMC6268734 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature