Bio-Oriented Synthesis of Novel Polyhydroquinoline Derivatives as α-Glucosidase Inhibitor for Management of Diabetes.

ABSTRACT: Polyhydroquinoline derivatives (1-15) were synthesized through an unsymmetrical Hantzsch reaction in excellent yields by treating 3,5-dibromo-4-hydroxybenzaldehyde, dimedone, ammonium acetate, and ethyl acetoacetate in ethanol solvent. The structures of the synthesized compounds (1-15) were deduced through different spectroscopic techniques such as ¹H NMR, ¹³C NMR, and HR-ESI-MS. The synthesized products were tested for their α-glucosidase inhibitory activity where compounds 11 (IC₅₀ = 0.56 ± 0.01 μM), 10 (IC₅₀ = 0.94 ± 0.01 μM), 4 (IC₅₀ = 1.47 ± 0.01 μM), 2 (IC₅₀ = 2.20 ± 0.03 μM), 6 (IC₅₀ = 2.20 ± 0.03 μM), 12 (IC_50</

SUBMITTER: Talab F 

PROVIDER: S-EPMC9948207 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature