A Common DIO2 Polymorphism and Alzheimer Disease Dementia in African and European Americans.

ABSTRACT:

Context

A common single nucleotide polymorphism in DIO2, Thr92AlaD2, has been associated with a transcriptome typically found in neurodegenerative diseases in postmortem human brain tissue.

Objective

To determine whether Thr92AlaD2 is associated with incident Alzheimer disease (AD).

Design

Population-based study; human brain tissue microarray.

Setting

Community-based cohorts from Chicago and northeastern Illinois and religious clergymen from across the United States constituted the primary population. A representative sample of the U.S. population was used for secondary analyses.

Participants

3054 African Americans (AAs) and 9304 European Americans (EAs).

Main outcome measure

Incident AD.

Results

In the primary population, AAs with Thr92Ala

SUBMITTER: McAninch EA 

PROVIDER: S-EPMC6276710 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature