Breathprinting Reveals Malaria-Associated Biomarkers and Mosquito Attractants.

ABSTRACT: Current evidence suggests that malarial infection could alter metabolites in the breath of patients, a phenomenon that could be exploited to create a breath-based diagnostic test. However, no study has explored this in a clinical setting. To investigate whether natural human malarial infection leads to a characteristic breath profile, we performed a field study in Malawi. Breath volatiles from children with and those without uncomplicated falciparum malaria were analyzed by thermal desorption-gas chromatography/mass spectrometry. Using an unbiased, correlation-based analysis, we found that children with malaria have a distinct shift in overall breath composition. Highly accurate classification of infection status was achieved with a suite of 6 compounds. In addition, we found that infectio

SUBMITTER: Schaber CL 

PROVIDER: S-EPMC6279169 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature