Short- and long-term impact of remifentanil on thermal detection and pain thresholds after cardiac surgery: A randomised controlled trial.

ABSTRACT:

Background

The clinical relevance of the suggested hyperalgesic effects of remifentanil is still unclear, especially in the long term.

Objective

The current study evaluated the impact of remifentanil on thermal thresholds 3 days and 12 months after surgery, measured with Quantitative Sensory Testing.

Design

A single-blind, randomised controlled trial.

Setting

A tertiary care teaching hospital in The Netherlands, from 2014 to 2016.

Patients

A total of 126 patients aged between 18 and 85 years, undergoing cardiothoracic surgery via sternotomy (coronary artery bypass grafts and/or valve replacement) were included. Exclusion criteria were BMI above 35 kg m, history of cardiac surgery, chronic pain conditions, neurological conditions, allergy to opioids or pa

SUBMITTER: de Hoogd S 

PROVIDER: S-EPMC6286874 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature