Immune cell counts and signaling in body fluids of cows vaccinated against Clostridium difficile.

ABSTRACT:

Background

New treatment options are needed to prevent relapses following failed antibiotic therapies of Clostridium difficile infections (CDI) in humans. The concomitant therapy with an anti-C. difficile IgA containing whey protein concentrate can support the sustainable recovery of CDI patients. For 31 weeks, nine dairy cows were continuously vaccinated with several anti-C. difficile vaccines by certain routes of administration to produce anti-C. difficile IgA enriched milk. The study aimed at finding decisive differences between low responder (LR) and high responder (HR) cows (> 8.0 µg ml^-1 total milk C. difficile specific IgA) concerning their immune response to vaccination on cellular and molecular biological levels.

Results

SUBMITTER: Schmautz C 

PROVIDER: S-EPMC6288880 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature