Mature dendritic cells correlate with favorable immune infiltrate and improved prognosis in ovarian carcinoma patients.

ABSTRACT: A high density of tumor-infiltrating CD8⁺ T cells and CD20⁺ B cells correlates with prolonged survival in patients with a wide variety of human cancers, including high-grade serous ovarian carcinoma (HGSC). However, the potential impact of mature dendritic cells (DCs) in shaping the immune contexture of HGSC, their role in the establishment of T cell-dependent antitumor immunity, and their potential prognostic value for HGSC patients remain unclear. We harnessed immunohistochemical tests and biomolecular analyses to demonstrate that a high density of tumor-infiltrating DC-LAMP⁺ DCs is robustly associated with an immune contexture characterized by T_H1 polarization and cytotoxic activity. We showed that both mature DCs and CD20⁺ B cells

SUBMITTER: Truxova I 

PROVIDER: S-EPMC6288908 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature