Involvement of different neuronal components in the induction of cortical plasticity with associative stimulation.

ABSTRACT:

Background

Paired associative stimulation (PAS), with stimulus interval of 21.5 or 25 ms, using transcranial magnetic stimulation in the posterior-anterior (PA) current direction, produces a long-term-potentiation-like effect. Stimulation with PA directed current generates both early and late indirect (I)-waves while that in anterior-posterior (AP) current predominantly elicits late I-waves. Short interval intracortical inhibition (SICI) inhibits late I-waves but not early I-waves.

Objective

To investigate how cortical inhibition modulates the effects of PAS.

Methods

PAS at stimulus interval of 21.5 ms conditioned by SICI (SICI-PAS) was compared to PAS alone with both PA and AP directed currents.

Results

PAS with both current directions increased cortical excit

SUBMITTER: Ni Z 

PROVIDER: S-EPMC6301109 | biostudies-literature | 2019 Jan - Feb

REPOSITORIES: biostudies-literature