Molecular and functional heterogeneity of IL-10-producing CD4⁺ T cells.

ABSTRACT: IL-10 is a prototypical anti-inflammatory cytokine, which is fundamental to the maintenance of immune homeostasis, especially in the intestine. There is an assumption that cells producing IL-10 have an immunoregulatory function. However, here we report that IL-10-producing CD4⁺ T cells are phenotypically and functionally heterogeneous. By combining single cell transcriptome and functional analyses, we identified a subpopulation of IL-10-producing Foxp3^neg CD4⁺ T cells that displays regulatory activity unlike other IL-10-producing CD4⁺ T cells, which are unexpectedly pro-inflammatory. The combinatorial expression of co-inhibitory receptors is sufficient to discriminate IL-10-producing CD4⁺ T cells with regulatory function from others an

SUBMITTER: Brockmann L 

PROVIDER: S-EPMC6303294 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature