Hot spot prediction in protein-protein interactions by an ensemble system.

ABSTRACT:

Background

Hot spot residues are functional sites in protein interaction interfaces. The identification of hot spot residues is time-consuming and laborious using experimental methods. In order to address the issue, many computational methods have been developed to predict hot spot residues. Moreover, most prediction methods are based on structural features, sequence characteristics, and/or other protein features.

Results

This paper proposed an ensemble learning method to predict hot spot residues that only uses sequence features and the relative accessible surface area of amino acid sequences. In this work, a novel feature selection technique was developed, an auto-correlation function combined with a sliding window technique was applied to obtain the characteristics of ami

SUBMITTER: Liu Q 

PROVIDER: S-EPMC6311905 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature