Circulating high sensitivity C reactive protein concentrations and risk of lung cancer: nested case-control study within Lung Cancer Cohort Consortium.

ABSTRACT:

Objectives

To conduct a comprehensive analysis of prospectively measured circulating high sensitivity C reactive protein (hsCRP) concentration and risk of lung cancer overall, by smoking status (never, former, and current smokers), and histological sub-type.

Design

Nested case-control study.

Setting

20 population based cohort studies in Asia, Europe, Australia, and the United States.

Participants

5299 patients with incident lung cancer, with individually incidence density matched controls.

Exposure

Circulating hsCRP concentrations in prediagnostic serum or plasma samples.

Main outcome measure

Incident lung cancer diagnosis.

Results

A positive association between circulating hsCRP concentration and the risk of lung cancer for current (odds r

SUBMITTER: Muller DC 

PROVIDER: S-EPMC6315896 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature