Optimization of Sample Preparation for Detection of 10 Phthalates in Non-Alcoholic Beverages in Northern Vietnam.

ABSTRACT: A novel method was developed for the sensitive, cheap and fast quantitation of 10 phthalates in non-alcoholic beverages by liquid⁻liquid extraction (LLE) combined with gas chromatography tandem mass spectrometry (GC-MS/MS). The best results were obtained when n-hexane was used as extraction solvent. A central composite design (CCD) was applied to select the most appreciated operating condition. The method performance was evaluated according to the SANTE/11945/2015 guidelines and was linear in the 0.1 to 200 µg/L range for 10 phthalate compounds, with r² > 0.996 and individual residuals <15%. Repeatability (RSD_r), within-laboratory reproducibility (RSD_wr), and the trueness range were from 2.7 to 9.1%, from 3.4 to 14.3% and from 91.5 to 118.1%, respectivel

SUBMITTER: Tran-Lam TT 

PROVIDER: S-EPMC6316763 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature