Association Between Family History and Early-Onset Atrial Fibrillation Across Racial and Ethnic Groups.

ABSTRACT:

Importance

There is a genetic predisposition to early-onset atrial fibrillation (EOAF) in European American individuals. However, the role of family history in the pathogenesis of EOAF in racial and ethnic minorities remains unclear.

Objective

To determine whether probands with EOAF across racial and ethnic groups have a higher rate of AF in first-degree family members than racially and ethnically matched control patients with non-early-onset AF (non-EOAF).

Design, setting, and participants

In this cohort study, patients prospectively enrolled in a clinical and genetic biorepository were administered baseline questionnaires that included questions about family history of AF. Early-onset AF was defined as AF occurring in probands aged 60 years or younger in the absence

SUBMITTER: Alzahrani Z 

PROVIDER: S-EPMC6324458 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature