IL-17A contributes to HSV1 infection-induced acute lung injury in a mouse model of pulmonary fibrosis.

ABSTRACT:

Background

Patients with idiopathic pulmonary fibrosis (IPF) often experience acute exacerbation (AE) after an episode of common cold.

Aims

To establish a mouse model of virus infection-induced AE-IPF and investigate the mechanism underlying the AE-IPF.

Methods

Herpes simplex virus 1 (HSV1) was inoculated intranasally to wild-type (WT) and IL-17A gene knockout (IL-17A^-/- ) mice 21 days after intratracheal administration of bleomycin (BLM).

Results

HSV1 infection caused acute exacerbation in mice with BLM-induced fibrosis. Compared with the BLM+Saline mice, the mice with BLM+HSV1 showed significantly higher acute lung injury (ALI) score (P < 0.0001), lower survival rate (100% vs 21.4%, P < 0.0001), poorer lung function and higher inflammatory response

SUBMITTER: Chen T 

PROVIDER: S-EPMC6349191 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature