Ontology highlight
ABSTRACT:
SUBMITTER: Liu L
PROVIDER: S-EPMC6349937 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Nature communications 20190128 1
Integrative analysis of multi-omics layers at single cell level is critical for accurate dissection of cell-to-cell variation within certain cell populations. Here we report scCAT-seq, a technique for simultaneously assaying chromatin accessibility and the transcriptome within the same single cell. We show that the combined single cell signatures enable accurate construction of regulatory relationships between cis-regulatory elements and the target genes at single-cell resolution, providing a ne ...[more]