Dataset Information

Hypofractionated Radiotherapy for Anaplastic Thyroid Carcinoma: 15 Years of Experience in a Single Institution.

ABSTRACT:

Background

Anaplastic thyroid carcinoma (ATC) is a rare cancer and has a poor prognosis. Several radiation protocols have been reported, but the results were not satisfactory.

Objective

The aim of this study was to determine the effect of hypofractionated radiotherapy.

Methods

Thirty-three patients who received radiotherapy for ATC between January 2000 and December 2014 were retrospectively included. We defined hypofractionated radiotherapy as a single dose ≥5 Gy.

Results

Nineteen patients were treated with hypofractionated radiotherapy. Twenty-eight patients died, and 27 of those patients died from ATC. Sixteen patients died from distant metastasis and 6 from local recurrence. In the hypofractionated radiotherapy group, local recurrence occurred in 5 patients and 1 of them died from active bleeding from a local tumor. There was local recurrence in 7 patients who received the other protocol, and 5 of them died from asphyxiation, active bleeding, or uncontrollable growth of a local tumor on the neck. The median overall survival (OS) was 5 months. In multivariate analysis, patients who received an equivalent dose in 2-Gy fractions (EQD₂) ≥50 Gy had significantly better OS (p = 0.016). In univariate analysis, patients who received hypofractionated radiotherapy did not have significantly better OS (p = 0.872) or local control (p = 0.090). The χ² test showed that significantly fewer patients died from local recurrence in the hypofractionated radiotherapy group (p = 0.025).

Conclusions

Multivariate analysis showed that an EQD₂ ≥50 Gy resulted in better OS, and hypofractionated radiotherapy decreased the rate of mortality from local recurrence.

SUBMITTER: Takahashi N

PROVIDER: S-EPMC6381908 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Hypofractionated Radiotherapy for Anaplastic Thyroid Carcinoma: 15 Years of Experience in a Single Institution.

Takahashi Noriyoshi N Matsushita Haruo H Umezawa Rei R Yamamoto Takaya T Ishikawa Yojiro Y Katagiri Yu Y Tasaka Shun S Takeda Kazuya K Fukui Katsuya K Kadoya Noriyuki N Ito Kengo K Jingu Keiichi K

European thyroid journal 20181004 1

<h4>Background</h4>Anaplastic thyroid carcinoma (ATC) is a rare cancer and has a poor prognosis. Several radiation protocols have been reported, but the results were not satisfactory.<h4>Objective</h4>The aim of this study was to determine the effect of hypofractionated radiotherapy.<h4>Methods</h4>Thirty-three patients who received radiotherapy for ATC between January 2000 and December 2014 were retrospectively included. We defined hypofractionated radiotherapy as a single dose ≥5 Gy.<h4>Result ...[more]

PMID: 30800638

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Dataset Information

Hypofractionated Radiotherapy for Anaplastic Thyroid Carcinoma: 15 Years of Experience in a Single Institution.

Background

Objective

Methods

Results

Conclusions

Publications

Hypofractionated Radiotherapy for Anaplastic Thyroid Carcinoma: 15 Years of Experience in a Single Institution.

Similar Datasets

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