Durability of symptomatic responses obtained with adjunctive vagus nerve stimulation in treatment-resistant depression.

ABSTRACT:

Objective

To compare the durations of response achieved with adjunctive vagus nerve stimulation (VNS + TAU) vs treatment as usual (TAU) alone in treatment-resistant depression (TRD) over a 5-year period in the TRD registry.

Materials and methods

Data from 271 participants on TAU and 328 participants on VNS + TAU were analyzed. Response was defined as ≥50% decrease in baseline Montgomery-Åsberg Depression Rating Scale (MADRS) score at postbaseline visit and was considered retained until the decrease was <40%. MADRS was obtained quarterly in year 1 and biannually thereafter. Time-to-events were estimated using Kaplan-Meier method and compared using log-rank test. HR was estimated using Cox proportion hazard model.

Results

In the VNS + TAU arm, 62.5% (205/328) of partici

SUBMITTER: Kumar A 

PROVIDER: S-EPMC6387594 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature