Ontology highlight
ABSTRACT:
SUBMITTER: Alkan HF
PROVIDER: S-EPMC6390946 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Cell metabolism 20180816 5
Mitochondrial function is important for aspartate biosynthesis in proliferating cells. Here, we show that mitochondrial aspartate export via the aspartate-glutamate carrier 1 (AGC1) supports cell proliferation and cellular redox homeostasis. Insufficient cytosolic aspartate delivery leads to cell death when TCA cycle carbon is reduced following glutamine withdrawal and/or glutaminase inhibition. Moreover, loss of AGC1 reduces allograft tumor growth that is further compromised by treatment with t ...[more]