Combined ∆⁹-tetrahydrocannabinol and moderate alcohol administration: effects on ingestive behaviors in adolescent male rats.

ABSTRACT:

Rationale

Whereas co-use of alcohol and marijuana is prevalent in adolescents, the effects of such drug co-exposure on ingestive and cognitive behaviors remain largely unexplored. We hypothesized that co-exposure to alcohol and ∆⁹-tetrahydrocannabinol (THC), the main psychoactive constitute of marijuana, alters feeding behavior and cognition differently from either drug alone.

Methods

Male rats received daily THC (3-20 mg/kg/day) or oil vehicle through subcutaneous injection or consumption of a cookie with access to saccharin or saccharin-sweetened alcohol during adolescence (P30-45). Barnes maze and sucrose preference tests were applied to assess spatial memory and behavioral flexibility and abstinence-related anhedonia, respectively.

Results

Subcutaneous

SUBMITTER: Nelson NG 

PROVIDER: S-EPMC6401297 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature