M⁶A: Widespread regulatory control in virus replication.

ABSTRACT: N⁶-methyladenosine (m⁶A) is a highly pervasive and dynamic modification found on eukaryotic RNA. Despite the failure to comprehend the true regulatory potential of this epitranscriptomic mark for decades, our knowledge of m⁶A has rapidly expanded in recent years. The modification has now been functionally linked to all stages of mRNA metabolism and demonstrated to regulate a variety of biological processes. Furthermore, m⁶A has been identified on transcripts encoded by a wide range of viruses. Studies to investigate m⁶A function in viral-host interactions have highlighted distinct roles indicating widespread regulatory control over viral life cycles. As a result, unveiling the true influence of m⁶A modification could revolut

SUBMITTER: Manners O 

PROVIDER: S-EPMC6414752 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature