¹⁸F-THK5351 PET Imaging in the Behavioral Variant of Frontotemporal Dementia.

ABSTRACT:

Background and purpose

Behavioral variant frontotemporal dementia (bvFTD) is a subtype of frontotemporal dementia, which has clinical symptoms of progressive personality and behavioral changes with deterioration of social cognition and executive functions. The pathology of bvFTD is known to be tauopathy or TDP-43 equally. We analyzed the ¹⁸F-THK5351 positron emission tomography (PET) scans, which were recently developed tau PET, in patients with clinically-diagnosed bvFTD.

Methods

Forty-eight participants, including participants with behavioral variant frontotemporal dementia (bvFTD, n=3), Alzheimer's disease (AD, n=21) and normal cognition (NC, n=24) who completed 3T magnetic resonance images, ¹⁸F-THK5351 PET scans, and detailed ne

SUBMITTER: Nam G 

PROVIDER: S-EPMC6425882 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature