Potassium chloride released from contracting skeletal muscle may stimulate development of its hypertrophy.
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ABSTRACT:
SUBMITTER: Kravchenko IV
PROVIDER: S-EPMC6433999 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
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Potassium chloride released from contracting skeletal muscle may stimulate development of its hypertrophy.
Kravchenko Irina V IV Furalyov Vladimir A VA Popov Vladimir O VO
Biochemistry and biophysics reports 20190321
The effects of potassium chloride on the expression of IGF-1 splice forms and myoblast proliferation were investigated. KCl at the concentrations of 7-12 mM stimulated the synthesis of IGF-1 and mechano growth factor (MGF) in murine myoblasts as well as in myotubes both at the mRNA and protein levels. Pan-calcium channel blocker CdCl<sub>2</sub> completely abolished stimulation of growth factor expression, whereas blocker of HCN and Na<sub>v</sub>1.4 channels ZD7288 drastically reduced it. In ad ...[more]
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