Modular ³¹ P wideband inversion transfer for integrative analysis of adenosine triphosphate metabolism, T₁ relaxation and molecular dynamics in skeletal muscle at 7T.

ABSTRACT:

Purpose

For efficient and integrative analysis of de novo adenosine triphosphate (ATP) synthesis, creatine-kinase-mediated ATP synthesis, T₁ relaxation time, and ATP molecular motion dynamics in human skeletal muscle at rest.

Methods

Four inversion-transfer modules differing in center inversion frequency were combined to generate amplified magnetization transfer (MT) effects in targeted MT pathways, including Pi ↔ γ-ATP, PCr ↔ γ-ATP, and ³¹ P_γ(α)ATP ↔ ³¹ P_βATP . MT effects from both forward and reverse exchange kinetic pathways were acquired to reduce potential bias and confounding factors in integrated data analysis.

Results

Kinetic data collected using 4 wideband inversion modules (8 minutes each) yielded the fo

SUBMITTER: Ren J 

PROVIDER: S-EPMC6435387 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature