Mus musculus deficient for secretory antibodies show delayed growth with an altered urinary metabolome.

ABSTRACT:

Background

The polymeric immunoglobulin receptor (pIgR) maintains the integrity of epithelial barriers by transporting polymeric antibodies and antigens through the epithelial mucosa into the lumen. In this study, we examined the role of pIgR in maintaining gut barrier integrity, which is important for the normal development in mice.

Methods

Cohorts of pIgR^-/- mice and their wildtype controls were housed under Specific Pathogen Free (SPF) conditions and monitored for weight gain as an indicator of development over time. The general physiology of the gastrointestinal tract was analysed using immunohistochemistry in young (8-12 weeks of age) and aged mice (up to 18 months of age), and the observed immunopathology in pIgR^-/- mice was further characterised

SUBMITTER: Simpfendorfer KR 

PROVIDER: S-EPMC6446318 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature