Perm1 regulates CaMKII activation and shapes skeletal muscle responses to endurance exercise training.

ABSTRACT:

Objective

Endurance exercise training remodels skeletal muscle, leading to increased mitochondrial content and oxidative capacity. How exercise entrains skeletal muscle signaling pathways to induce adaptive responses remains unclear. In past studies, we identified Perm1 (PGC-1 and ERR induced regulator, muscle 1) as an exercise-induced gene and showed that Perm1 overexpression elicits similar muscle adaptations as endurance exercise training. The mechanism of action and the role of Perm1 in exercise-induced responses are not known. In this study, we aimed to determine the pathway by which Perm1 acts as well as the importance of Perm1 for acute and long-term responses to exercise.

Methods

We performed immunoprecipitation and mass spectrometry to identify Perm1 associated prot

SUBMITTER: Cho Y 

PROVIDER: S-EPMC6480336 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature