Composition-Tunable Ultrasmall Manganese Ferrite Nanoparticles: Insights into their In Vivo T₁ Contrast Efficacy.

ABSTRACT: The development of a highly efficient, low-toxicity, ultrasmall ferrite nanoparticle-based T₁ contrast agent for high-resolution magnetic resonance imaging (MRI) is highly desirable. However, the correlations between the chemical compositions, in vitro T₁ relaxivities, in vivo nano-bio interactions and toxicities remain unclear, which has been a challenge in optimizing the in vivo T₁ contrast efficacy. Methods: Ultrasmall (3 nm) manganese ferrite nanoparticles (Mn_xFe_3-xO₄) with different doping concentrations of the manganese ions (x = 0.32, 0.37, 0.75, 1, 1.23 and 1.57) were used as a model system to investigate the composition-dependence of the in vivo T₁ contrast efficacy. The

SUBMITTER: Miao Y 

PROVIDER: S-EPMC6485191 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature