Identifying dementia outcomes in UK Biobank: a validation study of primary care, hospital admissions and mortality data.

ABSTRACT: Prospective, population-based studies that recruit participants in mid-life are valuable resources for dementia research. Follow-up in these studies is often through linkage to routinely-collected healthcare datasets. We investigated the accuracy of these datasets for dementia case ascertainment in a validation study using data from UK Biobank-an open access, population-based study of > 500,000 adults aged 40-69 years at recruitment in 2006-2010. From 17,198 UK Biobank participants recruited in Edinburgh, we identified those with ≥ 1 dementia code in their linked primary care, hospital admissions or mortality data and compared their coded diagnoses to clinical expert adjudication of their full-text medical record. We calculated the positive predictive value (PPV, the proportion of cases id

SUBMITTER: Wilkinson T 

PROVIDER: S-EPMC6497624 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature