Reversal of established liver fibrosis by IC-2-engineered mesenchymal stem cell sheets.

ABSTRACT: Chronic hepatitis viral infection, alcoholic intoxication, and obesity cause liver fibrosis, which progresses to decompensated liver cirrhosis, a disease for which medical demands cannot be met. Since there are currently no approved anti-fibrotic therapies for established liver fibrosis, the development of novel modalities is required to improve patient prognosis. In this study, we clarified the anti-fibrotic effects of cell sheets produced from human bone marrow-derived mesenchymal stem cells (MSCs) incubated on a temperature-sensitive culture dish with the chemical compound IC-2. Orthotopic transplantation of IC-2-engineered MSC sheets (IC-2 sheets) remarkably reduced liver fibrosis induced by chronic CCl₄ administration. Further, the marked production of fibrolytic enzymes su

SUBMITTER: Itaba N 

PROVIDER: S-EPMC6497888 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature