Dataset Information

Clinical and endoscopic findings to assist the early detection of duodenal adenoma and adenocarcinoma.

ABSTRACT:

Background

Sporadic nonampullary duodenal adenocarcinoma is a rare malignant neoplasm in which poor prognosis is often associated with delayed diagnosis.

Objective

A case-control study was designed to evaluate the clinical and endoscopic characteristics of patients with nonampullary duodenal epithelial tumours (NADETs).

Methods

Patients with NADETs were chronologically divided into a discovery and a validation sets. Two age- and sex-matched control individuals for each case in the discovery set were randomly selected from individuals without NADET. A prediction model for the presence of NADET, constructed in the discovery set, was evaluated in the validation set.

Results

In total, 368 adenomas, 81 adenocarcinomas, and 314 controls were analysed. Current smoking, Barrett oesophagus, fundic gland polyps, history of malignant disease, and absence of dyslipidaemia were independently associated with the presence of NADET. The combination of these five factors enabled significant discrimination for NADET in the bulb with a sensitivity of 0.81 in the validation set. We also showed that duodenal adenocarcinomas in the bulb had greater invasive potential than adenocarcinomas in the second portion.

Conclusion

The presence of a duodenal tumour in the bulb could be predicted by clinical and endoscopic findings, which helps improve the prognosis and quality of life of patients.

SUBMITTER: Matsuzaki J

PROVIDER: S-EPMC6498797 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Publications

Clinical and endoscopic findings to assist the early detection of duodenal adenoma and adenocarcinoma.

Matsuzaki Juntaro J Suzuki Hidekazu H Shimoda Masayuki M Mori Hideki H Fukuhara Seiichiro S Miyoshi Sawako S Masaoka Tatsuhiro T Iwao Yasushi Y Kanai Yae Y Kanai Takanori T

United European gastroenterology journal 20181203 2

<h4>Background</h4>Sporadic nonampullary duodenal adenocarcinoma is a rare malignant neoplasm in which poor prognosis is often associated with delayed diagnosis.<h4>Objective</h4>A case-control study was designed to evaluate the clinical and endoscopic characteristics of patients with nonampullary duodenal epithelial tumours (NADETs).<h4>Methods</h4>Patients with NADETs were chronologically divided into a discovery and a validation sets. Two age- and sex-matched control individuals for each case ...[more]

PMID: 31080610

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Project description:BackgroundDuodenal papillary adenoma, a potentially malignant benign tumor is primarily treated with endoscopic papillectomy. Despite its efficacy, endoscopic papillectomy has a high complication rate. This study investigates whether pancreatic duct and common bile duct stent placement can mitigate these complications.MethodsIn a retrospective observational analysis, 79 patients with duodenal papillary adenoma, treated with endoscopic papillectomy at our center, were studied. The cohort included patients who underwent endoscopic papillectomy with no stents placement, common bile duct stent placement alone, pancreatic duct stent placement alone, or stents placement in both ducts. We assessed the outcomes of endoscopic papillectomy, including complete resection rate and recurrence rate as the primary and secondary outcomes respectively. In the meantime, the incidence of complications were also analysed as the safety outcomes.ResultsComplete resection rates did not significantly differ between patients with or without stent placement (85.7% P group vs. 89.2% N-P group, P = 0.64). Early complication rates were similar across groups. However, significant reduction in common bile duct stenosis was observed in the stenting group (0% B group vs. 10.5% N-B group, P = 0.03). Furthermore, stent placement correlated with lower adenoma recurrence rates during follow-up (2.4% P group vs. 16.2% N-P group, P = 0.03; 2.4% B group vs. 15.8% N-B group, P = 0.04).ConclusionsPancreatic duct and common bile duct stent placement in endoscopic papillectomy may decrease late complications, particularly common bile duct stenosis, and reduce the recurrence of duodenal papillary adenoma.Trial registrationThis study received approval from the Institutional Review Board and Ethics Committee of Beijing Friendship Hospital (Approval No. BFHHZS20230203), and retrospectively registered in www.Clinicaltrialsgov (NCT06301048, Initial Release date: 02/18/2024, Last Public Release date: 03/03/2024).

Dataset Information

Clinical and endoscopic findings to assist the early detection of duodenal adenoma and adenocarcinoma.

Background

Objective

Methods

Results

Conclusion

Publications

Clinical and endoscopic findings to assist the early detection of duodenal adenoma and adenocarcinoma.

Similar Datasets

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