Slow release oral morphine versus methadone for the treatment of opioid use disorder.

ABSTRACT:

Objective

To assess the efficacy of slow release oral morphine (SROM) as a treatment for opioid use disorder (OUD).

Design

Systematic review and meta-analysis of randomised controlled trials (RCTs).

Data sources

Three electronic databases were searched through 1 May 2018: the Cochrane Central Register of Controlled Trials, MEDLINE and EMBASE. We also searched the following electronic registers for ongoing trials: ClinicalTrials.gov, WHO International Clinical Trials Registry Platform, Current Controlled Trials and the EU Clinical Trials Register.

Eligibility criteria for selecting studies

We included RCTs of all durations, assessing the effect of SROM on measures of treatment retention, heroin use and craving in adults who met the diagnostic criteria for OUD.

SUBMITTER: Klimas J 

PROVIDER: S-EPMC6500187 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature