Salmonella enterica persister cells form unstable small colony variants after in vitro exposure to ciprofloxacin.

ABSTRACT: Persistence phenotype and small colony variants (SCVs) can be part of a bacterial bet-hedging strategy for survival under environmental stresses, such as antimicrobial exposure. These phenotypes are of particular concern in persistent and relapsing infections, since cells resume to normal growth after cessation of the stressful condition. In this context, we found persisters and unstable SCVs as phenotypic variants of Salmonella enterica that were able to survive ciprofloxacin exposure. A high heterogeneity in persister levels was observed among S. enterica isolates grown under planktonic and biofilm conditions and exposed to ciprofloxacin or ceftazidime, which may indicate persistence as a non-multidrug-tolerant phenotype. Nevertheless, a comparable variability was not found in the format

SUBMITTER: Drescher SPM 

PROVIDER: S-EPMC6510897 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature