Galanin is a potent modulator of cytokine and chemokine expression in human macrophages.

ABSTRACT: The regulatory peptide galanin is broadly distributed in the central- and peripheral nervous systems as well as in non-neuronal tissues, where it exerts its diverse physiological functions via three G-protein-coupled receptors (GAL_1-3-R). Regulatory peptides are important mediators of the cross-communication between the nervous- and immune systems and have emerged as a focus of new therapeutics for a variety of inflammatory diseases. Studies on inflammatory animal models and immune cells revealed both pro- and anti-inflammatory functions of galanin. Here, we probed specific immune-related functions of the galanin system and found galanin and GAL₁-R and GAL₂-R mRNA to be expressed in a range of human immune cells. In particular, macrophages displayed differe

SUBMITTER: Koller A 

PROVIDER: S-EPMC6510899 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature