MDM2, MDM2-C, and mutant p53 expression influence breast cancer survival in a multiethnic population.

ABSTRACT:

Purpose

The purpose of the study was to examine the association between expression of mutant p53 (mtp53), full-length MDM2 (MDM2), and MDM2 isoform C (MDM2-C) and survival in multiethnic breast cancer patients.

Methods

A total of 787 invasive breast tumors included in a clinically annotated multiethnic population-based tissue microarray (TMA) were screened utilizing commercially available antibodies to p53 and MDM2, and a newly developed monoclonal antibody recognizing MDM2-C.

Results

Mutant p53 (mtp53) was more common in younger (< 50 years) breast cancer patients. Among the 787 cases included in the study, mtp53, MDM2, and MDM2-C expression were not significantly associated with risk of overall or breast cancer-specific mortality. However when associations within in

SUBMITTER: Loo LWM 

PROVIDER: S-EPMC6530987 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature