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Invasion reproductive numbers for periodic epidemic models.

ABSTRACT: There are many cases within epidemiology where infections compete to persist within a population. In studying models for such cases, one of the goals is to determine which infections can invade a population and persist when other infections are already resident within the population. Invasion reproductive numbers (IRN), which are tied to the stability of boundary endemic equilibria, can address this question. By reinterpreting resident infections epidemiologically, this study extends methods for finding IRNs to periodic systems, and presents some examples which illustrate the often complex computations required. Results identify conditions under which a simple time-average can be used to derive IRNs, and apply the methods to examine how seasonal fluctuations in influenza incidence facilitate the year-round persistence of bacterial respiratory infections.

SUBMITTER: Mitchell C

PROVIDER: S-EPMC6531838 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Invasion reproductive numbers for periodic epidemic models.

Mitchell Christopher C Kribs Christopher C

Infectious Disease Modelling 20190426

There are many cases within epidemiology where infections compete to persist within a population. In studying models for such cases, one of the goals is to determine which infections can invade a population and persist when other infections are already resident within the population. Invasion reproductive numbers (IRN), which are tied to the stability of boundary endemic equilibria, can address this question. By reinterpreting resident infections epidemiologically, this study extends methods for ...[more]

PMID: 31193521

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