Optical Resolution of Rimantadine.

ABSTRACT: This work discloses a new procedure for the resolution of commercially available racemic rimantadine hydrochloride to enantiomerically pure (S)-rimantadine using (R)-phenoxypropionic acid as a recyclable resolving reagent. Good chemical yields, operational ease, and low-cost structure underscore the preparative value of this method for the production of enantiomerically pure rimantadine for medicinal or synthetic studies.

SUBMITTER: Han J 

PROVIDER: S-EPMC6539882 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature