Development of a biomarker panel to predict cardiac resynchronization therapy response: Results from the SMART-AV trial.

ABSTRACT:

Background

Predicting a favorable cardiac resynchronization therapy (CRT) response holds great clinical importance.

Objective

The purpose of this study was to examine proteins from broad biological pathways and develop a prediction tool for response to CRT.

Methods

Plasma was collected from patients before CRT (SMART-AV [SmartDelay Determined AV Optimization: A Comparison to Other AV Delay Methods Used in Cardiac Resynchronization Therapy] trial). A CRT response was prespecified as a ≥15-mL reduction in left ventricular end-systolic volume at 6 months, which resulted in a binary CRT response (responders 52%, nonresponders 48%; n = 758).

Results

Candidate proteins (n = 74) were evaluated from the inflammatory, signaling, and structural domains, which yielded 12

SUBMITTER: Spinale FG 

PROVIDER: S-EPMC6540994 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature