Evidence of heterogeneity in statin-associated type 2 diabetes mellitus risk: A meta-analysis of randomized controlled trials and observational studies.

ABSTRACT:

Aims

To conduct a meta-analysis of statin-associated type 2 diabetes mellitus (T2D) risk among randomized controlled trials (RCTs) and observational studies (OBSs), excluding studies conducted among secondary prevention populations.

Methods

Studies were identified by searching PubMed (1994-present) and EMBASE (1994-present). Articles had to meet the following criteria: (1) follow-up >one year; (2) >50% of participants free of clinically diagnosed ASCVD; (3) adult participants ≥30 years old; (4) reported statin-associated T2D effect estimates; and (5) quantified precision using 95% confidence interval. Data were pooled using random-effects model.

Results

We identified 23 studies (35% RCTs) of n = 4,012,555 participants. OBS participants were on average younger (mean di

SUBMITTER: Engeda JC 

PROVIDER: S-EPMC6544490 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature