Inflammatory cytokines in type 2 diabetes mellitus as facilitators of hypercoagulation and abnormal clot formation.

ABSTRACT:

Background

The global burden of type 2 diabetes mellitus (T2DM), together with the presence of cardiovascular risk in this population, is reaching pandemic levels. A prominent feature of T2DM is chronic and systemic inflammation, with the accompanying presence of circulating and dysregulated inflammatory biomarkers; which in turn is associated with abnormal clot formation.

Methods

Here, we investigate the correlation between abnormal blood clotting, using thromboelastography (TEG), clot ultrastructure using scanning electron microscopy (SEM) and the presence of a dysregulated inflammatory cytokine profile, by examining various circulating biomarkers.

Results

Our results show that many biomarkers, across TEG, cytokine and lipid groups, were greatly dysregulated in the

SUBMITTER: Randeria SN 

PROVIDER: S-EPMC6549308 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature