Metabolomic profile of diet-induced obesity mice in response to humanin and small humanin-like peptide 2 treatment.

ABSTRACT:

Introduction

The mitochondrial-derived peptides (MDPs) are a novel group of natural occurring peptides that have important signaling functions and biological activity. Both humanin and small-humanin-like peptide 2 (SHLP2) have been reported to act as insulin sensitizers and modulate metabolism.

Objectives

By using a metabolomic approach, this study explores how the plasma metabolite profile is regulated in response to humanin and SHLP2 treatment in a diet-induced obesity (DIO) mouse model. The results also shed light on the potential mechanism underlying MDPs' insulin sensitization effects.

Methods

Plasma samples were obtained from DIO mice subjected to vehicle (water) treatment, or peptide treatment with either humanin analog S14G (HNG) or SHLP2 (n = 6 per group). Ve

SUBMITTER: Mehta HH 

PROVIDER: S-EPMC6554247 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature