NZO/HlLtJ as a novel model for the studies on the role of metabolic syndrome in acute radiation toxicity.

ABSTRACT: Purpose: Growing rates of metabolic syndrome and associated obesity warrant the development of appropriate animal models for better understanding of how those conditions may affect sensitivity to IR exposure.Materials and methods: We subjected male NZO/HlLtJ mice, a strain prone to spontaneous obesity and diabetes, to 0, 5.5, 6.37, 7.4 or 8.5 Gy (¹³⁷Cs) of total body irradiation (TBI). Mice were monitored for 30 days, after which proximal jejunum and colon tissues were collected for further histological and molecular analysis.Results: Obese NZO/HlLtJ male mice are characterized by their lower sensitivity to IR at doses of 6.37 Gy and under, compared to other strains. Further escalation of the dose, however, results in a steep survival curve, reaching LD

SUBMITTER: Ewing LE 

PROVIDER: S-EPMC6581619 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature