Role of Tumor-Associated Macrophages in the Clinical Course of Pancreatic Neuroendocrine Tumors (PanNETs).

ABSTRACT:

Purpose

This study evaluated the potential role of immune cells and molecules in the pathogenesis and clinical course of pancreatic neuroendocrine tumors (PanNET).

Experimental design

Surgically resected PanNETs (N = 104) were immunohistochemically analyzed for Ki67 index, mitotic rate, macrophage, CD4⁺ cells, and CD8⁺ T-cell infiltration, as well as HLA class I, PD-L1, and B7-H3 expression. Results were correlated with clinicopathologic characteristics as well as with disease-free (DFS) and disease-specific (DSS) survival.

Results

The median age of the 57 WHO grade 1 and 47 WHO grade 2 patients was 55 years. High intratumoral CD8⁺ T-cell infiltration correlated with prolonged DFS (P = 0.05), especially when the number of

SUBMITTER: Cai L 

PROVIDER: S-EPMC6582654 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature