Association of the Infant Gut Microbiome With Early Childhood Neurodevelopmental Outcomes: An Ancillary Study to the VDAART Randomized Clinical Trial.

ABSTRACT:

Importance

In animal models, the early life gut microbiome influences later neurodevelopment. Corresponding data in human populations are lacking.

Objective

To study associations between the gut microbiome in infants and development at preschool age measured by the Ages and Stages Questionnaire, third edition (ASQ-3).

Design, setting, and participants

This ancillary cohort study of the Vitamin D Antenatal Asthma Reduction Trial (VDAART) used data from 715 participants who had development assessed at 3 years of age by the ASQ-3, which included scores in 5 domains (gross motor skills, fine motor skills, problem solving, communication, and personal and social skills). A total of 309 stool samples were collected from infants aged 3 to 6 months for microbiome analysis usin

SUBMITTER: Sordillo JE 

PROVIDER: S-EPMC6583279 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature