<i>APOE</i> genotype influences the gut microbiome structure and function in humans and mice: relevance for Alzheimer's disease pathophysiology.

ABSTRACT: Apolipoprotein E (APOE) genotype is the strongest prevalent genetic risk factor for Alzheimer's disease (AD). Numerous studies have provided insights into the pathologic mechanisms. However, a comprehensive understanding of the impact of APOE genotype on microflora speciation and metabolism is completely lacking. In this study, we investigated the association between APOE genotype and the gut microbiome composition in human and APOE-targeted replacement (TR) transgenic mice. Fecal microbiota amplicon sequencing from matched individuals with different APOE genotypes revealed no significant differences in overall microbiota diversity in group-aggregated human APOE genotypes. However, several bacterial taxa showed significantly different relative abun

SUBMITTER: Tran TTT 

PROVIDER: S-EPMC6593891 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature